Hippocampal epileptogenesis in autoimmune encephalitis
نویسندگان
چکیده
منابع مشابه
O 16: Challenge in Diagnosis and Management of Autoimmune Encephalitis
The first description of an autoimmune encephalitis dates back to 1888, when Hermann Oppenheim described a patient with neurological symptoms but no underlying brain pathology. The field of autoimmune encephalitides associated with antibodies targeting cell-surface antigens is rapidly expanding and new antibodies are discovered frequently. Autoimmune encephalitis is a difficult clinical diagnos...
متن کاملAutoimmune Encephalitis
autoimmune encephalitis (aiE) associated with neural autoantibodies is increasingly recognized as a cause of subacute onset amnesia, confusion, and seizures. in the past decade, several key antibody targets have been identified in aiE. These include the N-methyl d-aspartate (NMda) receptors, voltage-gated potassium channel complexes—in particular leucine-rich glioma inactivated 1 (lGi1) and glu...
متن کاملAutoimmune Encephalitis.
The term autoimmune encephalitis is used to describe a group of disorders characterised by symptoms of limbic and extra-limbic dysfunction occurring in association with antibodies against synaptic antigens and proteins localised on the neuronal cell surface. In recent years there has been a rapidly expanding knowledge of these syndromes resulting in a shift in clinical paradigms and new insight...
متن کاملGlutamate Dysregulation and Hippocampal Dysfunction in Epileptogenesis
OF THESIS GLUTAMATE DYSREGULATION AND HIPPOCAMPAL DYSFUNCTION IN EPILEPTOGENESIS Epileptogenesis is the complex process of the brain developing epileptic acitivity. Due to the role of glutamate and the hippocampus in synaptic plasticity a dysregulation in glutamate neurotransmission and hippocampal dysfunction are implicated in the process of epileptogenesis. However, the exact causal factors t...
متن کاملO 19: Treatment and Porognosis of Autoimmune Encephalitis
AE is a serious medical condition in which the immune system attacks the brain, impairing function. With rapid diagnosis and appropriate treatment, many patients recover most or all functions. However, not all patients experience full recovery; with approximately 6% mortality and other patients who never regain significant brain and/or bodily functions. Autoimmune encephalitis can pro...
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ژورنال
عنوان ژورنال: Annals of Clinical and Translational Neurology
سال: 2019
ISSN: 2328-9503,2328-9503
DOI: 10.1002/acn3.50919